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  • Review: antidepressants plus benzodiazepines lead to fewer drop outs and less depression severity in major depression

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Therapeutics
Review: antidepressants plus benzodiazepines lead to fewer drop outs and less depression severity in major depression

https://doi.org/10.1136/ebm.6.6.184

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    ; Furukawa T, Streiner DL, Young LT.Antidepressant plus benzodiazepine for major depression. Cochrane Database Syst Rev 2000;(4):CD001026 (latest version 29 Aug 2000)..
    (2001) J Affect Disord 65, 173. Furukawa TA, Streiner DL, Young LT.. Is antidepressant-benzodiazepine combination therapy clinically more useful? A meta-analytic study.. Jul;. :. –7.
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 QUESTION: In adults with major depression, does combination treatment with antidepressants and benzodiazepines lead to short term (< 8 wk) or long term (> 2 mo) symptomatic recovery or side effects?

    Data sources

    Studies were identified by searching Medline, EMBASE/Excerpta Medica, International Pharmaceutical Abstracts, Biological Abstracts, LILACS, PsycLIT, the Cochrane Library, and the trial register of the Cochrane Depression, Anxiety, and Neurosis Group (January 1972 to December 1998); hand searching major mental health and general medicine journals; scanning thereference lists of identified articles; checking SciSearch; and making personal contacts.

    Study selection

    Studies were selected if they were randomised controlled trials comparing combined antidepressantbenzodiazepine treatment with antidepressants alone in adults with major depression. Studies were excluded if the antidepressant dose was < 100 mg of imipramine, or its equivalent daily, or the duration of the trial was < 4 weeks.

    Data extraction

    Data were extracted on patient …

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