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A negative quantitative latex d-dimer assay helped to rule out venous thromboembolism

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 QUESTION: In patients with suspected venous thromboembolism (VTE) (ie, deep venous thrombosis [DVT] or pulmonary embolism [PE]), can a quantitative latex d-dimer assay rule out VTE?


Blinded comparison of the results of the latex d-dimer test (MDA d-Dimer, Organon Teknika Corporation, Durham, NC, USA) with objective testing done at presentation and during follow up (3 mo).


4 tertiary care university medical centres in Ontario, Canada.


595 patients (60% women) with suspected VTE (317 with suspected DVT and 278 with suspected PE).

Description of tests and diagnostic standards

All patients had a clinical examination and were classified into low, intermediate, or high probability categories according to a previously validated model. Patients with suspected DVT …

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  • Source of funding: Organon Teknika Corporation.

  • For correspondence: Dr S M Bates, McMaster University Medical Centre, Thromboembolism Unit, HSC 3W15, 1200 Main Street West, Hamilton, Ontario L8V 1C3, Canada. Fax +1 905 521 4997.