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Diagnosis
A negative quantitative latex d-dimer assay helped to rule out venous thromboembolism

https://doi.org/10.1136/ebm.6.6.188

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    (2001) Arch Intern Med 161, 447; Bates SM, Grand'Maison A, Johnston M, et al.. A latexd-dimer reliably excludes venous thromboembolism.. Feb 12;. :. –53.
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 QUESTION: In patients with suspected venous thromboembolism (VTE) (ie, deep venous thrombosis [DVT] or pulmonary embolism [PE]), can a quantitative latex d-dimer assay rule out VTE?

    Design

    Blinded comparison of the results of the latex d-dimer test (MDA d-Dimer, Organon Teknika Corporation, Durham, NC, USA) with objective testing done at presentation and during follow up (3 mo).

    Setting

    4 tertiary care university medical centres in Ontario, Canada.

    Patients

    595 patients (60% women) with suspected VTE (317 with suspected DVT and 278 with suspected PE).

    Description of tests and diagnostic standards

    All patients had a clinical examination and were classified into low, intermediate, or high probability categories according to a previously validated model. Patients with suspected DVT …

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    Footnotes

    • Source of funding: Organon Teknika Corporation.

    • For correspondence: Dr S M Bates, McMaster University Medical Centre, Thromboembolism Unit, HSC 3W15, 1200 Main Street West, Hamilton, Ontario L8V 1C3, Canada. Fax +1 905 521 4997.