Article Text

Download PDFPDF
Oseltamivir was safe and effective for prophylaxis of influenza in the frail elderly

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 QUESTION: In frail older people in a residential setting, is oseltamivir (a neuraminidase inhibitor) safe and effective in preventing influenza A and B?


Randomised (allocation concealed** placebo controlled trial with 8 weeks of follow up.


31 residential homes or sheltered accommodations for seniors in 5 countries during the 1998–99 influenza season.


572 people who were ≥ 65 years of age, resided in care homes for seniors, and scored ≥ 7 on a Mental Status Questionnaire. Exclusion criteria included antibiotic treatment for acute upper respiratory tract infection, otitis media, bronchitis, or sinusitis, and antiviral treatment for influenza in the previous 2 weeks. 548 people (mean age 81 y, 69% women), of whom 80% were vaccinated against influenza, received ≥ 1 dose of study drug and …

View Full Text


  • Source of funding: F Hoffmann-La Roche AG.

  • For correspondence: Dr P H Peters Jr, South Texas Medical Research Associates, 6547 Bandera Road, Suite C, San Antonio, TX 78238, USA.

  • * See glossary.

  • p Value calculated from data in article.