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QUESTION: In frail older people in a residential setting, is oseltamivir (a neuraminidase inhibitor) safe and effective in preventing influenza A and B?
Randomised (allocation concealed** placebo controlled trial with 8 weeks of follow up.
31 residential homes or sheltered accommodations for seniors in 5 countries during the 1998–99 influenza season.
572 people who were ≥ 65 years of age, resided in care homes for seniors, and scored ≥ 7 on a Mental Status Questionnaire. Exclusion criteria included antibiotic treatment for acute upper respiratory tract infection, otitis media, bronchitis, or sinusitis, and antiviral treatment for influenza in the previous 2 weeks. 548 people (mean age 81 y, 69% women), of whom 80% were vaccinated against influenza, received ≥ 1 dose of study drug and …