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Therapeutics
Long term and short term oral anticoagulation treatments were equivalent for venous thromboembolism

https://doi.org/10.1136/ebm.7.1.16

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    (2001) Circulation 103, 2453. Pinede L, Ninet J, Duhaut P. , et al, for the Investigators of the “Durée Optimale du Traitement AntiVitamines K” (DOTAVK) Study. . Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis.. May 22;. :. –60.
    OpenUrlAbstract/FREE Full Text

    
 
 QUESTION: In patients with proximal deep venous thrombosis (PDVT) or pulmonary embolism, or both, or isolated calf deep venous thrombosis (CDVT), is long term treatment better than short term treatment with oral anticoagulants for preventing recurrences and bleeding complications?

    Design

    Randomised (allocation concealed*), unblinded,* controlled trial with 15 months of follow up.

    Setting

    France.

    Patients

    736 patients (mean age 59 y, 53% women) who had symptomatic PDVT or pulmonary embolism, or both, or symptomatic CDVT confirmed by objective diagnostic tests. Exclusion criteria included pregnancy, breast feeding, vena cava filter implantation, surgical thrombectomy, free-floating thrombus in the inferior vena cava, active cancer or malignant haematological disease, or a previous venous thromboembolism. 97% of patients completed the study.

    Intervention

    375 patients (270 with PDVT or pulmonary embolism, or both, and 105 with CDVT) were allocated to short term (3 mo for PDVT–pulmonary embolism, 6 wk for CDVT) oral anticoagulant treatment, and 361 patients (269 with PDVT or pulmonary embolism, or both, and 92 with CDVT) were allocated to long term (6 mo for PDVT–pulmonary embolism, 12 wk for CDVT) treatment with oral anticoagulants. Fluindione was used for oral anticoagulation with dose adjustments to …

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