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Progression of disease in HIV infected children slowed after the first year of life

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 QUESTION: In children with HIV infection at birth, what are the clinical and immunological manifestations of disease progression during the first 10 years of life?


Cohort study with a median 5.8 years of follow up.


11 paediatric centres in 7 European countries.


170 HIV infected children who were born to mothers known to be infected with HIV at the time of delivery.

Assessment of prognostic factors

Children were categorised into 3 cohorts according to the treatment policy at the time of their birth. Cohort 1 consisted of children born during 1985 to 1988 when no recommendations for treatment existed; cohort 2 consisted of children born during 1989 to 1994 when the treatment policy was restricted to monotherapy for symptomatic children; and cohort 3 consisted of children born during 1995 to 1999 when the initiation of combination treatments was recommended at an early stage. Children were allocated to Centers for Disease …

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  • A modified version of this abstract also appears in Evidence-Based Nursing.

  • Source of funding: Medical Research Council (UK).

  • For correspondence: Professor M L Newell, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.