Therapeutics
Review: platelet glycoprotein IIb/IIIa blockers for PCI or acute coronary syndromes reduce death and MI but increase bleeding
Bosch X, Marrugat J. Platelet glycoprotein IIb/IIIa blockers for percutaneous coronary revascularization, and unstable angina and non-ST-segment elevation myocardial infarction. Cochrane Database Syst Rev2001;(4):CD002130 (latest version 24 Aug 2001).
Abciximab did not reduce death or myocardial infarction in the acute coronary syndrome without early revascularization
The GUSTO IV-ACS Investigators. Effect of glycoprotein IIb/IIIa receptor blocker abciximab on outcome in patients with acute coronary syndromes without early coronary revascularisation: the GUSTO IV-ACS randomised trial. Lancet 2001 Jun 16;357:1915–24
Tenecteplase plus enoxaparin or abciximab was better than tenecteplase plus unfractionated heparin for acute MI
The Assessment of the Safety and Efficacy of a New Thrombolytic Regimen (ASSENT)-3 Investigators. Efficacy and safety of tenecteplase in combination with enoxaparin, abciximab, or unfractionated heparin: the ASSENT-3 randomised trial in acute myocardial infarction. Lancet 2001 Aug 25;358:605–13
Reteplase plus abciximab and reteplase alone led to similar 30-day mortality rates in acute MI
The GUSTO V Investigators. Reperfusion therapy for acute myocardial infarction with fibrinolytic therapy or combination reduced fibrinolytic therapy and platelet glycoprotein IIb/IIIa inhibition: the GUSTO V randomised trial. Lancet 2001 Jun 16;357:1905–14
Prone positioning for acute respiratory failure improved short-term oxygenation but not survival
Gattinoni L, Tognoni G, Presenti A,et al, for the Prone-Supine Study Group. Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med 2001 Aug 23;345:568–73
Itraconazole was as effective as amphotericin B for fever and neutropenia in cancer and led to fewer adverse events
Boogaerts M, Winston DJ, Bow EJ,et al, and the Itraconazole Neutropenia Study Group. Intravenous and oral itraconazole versus intravenous amphotericin B deoxycholate as empirical antifungal therapy for persistent fever in neutropenic patients with cancer who are receiving broad-spectrum antibacterial therapy. A randomized, controlled trial. Ann Intern Med 2001 Sep 18;135:412–22
Single-dose doxycycline prevented Lyme disease after an Ixodes scapularis tick bite
Nadelman RB, Nowakowski J, Fish D,et al, for the Tick Bite Study Group. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med 2001 Jul 12;345:79–84
Prolonged antibiotic treatment did not relieve chronic symptoms in Lyme disease
Klempner MS, Hu LT, Evans J,et al. Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. N Engl J Med 2001 Jul 12;345:85–92
A community support program for dementia delayed but did not reduce institutionalization over 2 years
Eloniemi-Sulkava U, Notkola IL, Hentinen M,et al. Effects of supporting community-living demented patients and their caregivers: a randomized trial. J Am Geriatr Soc 2001 Oct;49:1282–7
Donepezil improved the clinical state and quality of life in moderate-to-severe Alzheimer disease
Feldman H, Gauthier S, Hecker J,et al, and the Donepezil MSAD Study Investigators Group. A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease. Neurology 2001 Aug 28;57:613–20
PDF