Therapeutics

Review: platelet glycoprotein IIb/IIIa blockers for PCI or acute coronary syndromes reduce death and MI but increase bleeding


Abciximab did not reduce death or myocardial infarction in the acute coronary syndrome without early revascularization


Tenecteplase plus enoxaparin or abciximab was better than tenecteplase plus unfractionated heparin for acute MI


Reteplase plus abciximab and reteplase alone led to similar 30-day mortality rates in acute MI


Prone positioning for acute respiratory failure improved short-term oxygenation but not survival


Itraconazole was as effective as amphotericin B for fever and neutropenia in cancer and led to fewer adverse events


Single-dose doxycycline prevented Lyme disease after an Ixodes scapularis tick bite


Prolonged antibiotic treatment did not relieve chronic symptoms in Lyme disease


A community support program for dementia delayed but did not reduce institutionalization over 2 years


Donepezil improved the clinical state and quality of life in moderate-to-severe Alzheimer disease


Diagnosis

Clinical and radiologic evaluation had moderate sensitivity and specificity for detecting idiopathic pulmonary fibrosis


Quality improvement

Rule-based computerized reminders increased ordering of preventive services in an inpatient setting


Clinical prediction guide

The TIMI risk score predicted mortality in patients with ST-elevation myocardial infarction