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Continuous and intermittent sibutramine were equally effective at 44 weeks for reducing weight in obesity

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 QUESTION: In obese people, is sibutramine effective for reducing weight?


Randomised (allocation concealed*), blinded (investigators and patients),* placebo controlled trial with 44 weeks of follow up after randomisation.


108 private practices and 3 hospital outpatient departments in Germany.


1001 patients who were 18 to 65 years of age (mean age 43 y, 77% women), had a body mass index (BMI) of 30 to 40 kg/m2, and had ≥ 1 previous unsuccessful attempt at losing weight by using dietary measures. Exclusion criteria were serious cardiovascular or metabolic diseases; history of drug or alcohol abuse; need for antidepressants, β;-blockers, or any drugs influencing body weight; or inadequate contraception in women of childbearing age. 79% of patients completed the study; all patients were included in the analysis.


Patients who responded (ie, weight …

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  • * See glossary.

  • Source of funding: Knoll Deutschland GmbH

  • For correspondence: Dr A Wirth, Teutoburger-Wald-Klinik, Germany. wirthbr{at}