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Levodopa plus carbidopa before physiotherapy increased motor recovery after stroke

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 QUESTION: In patients who had a stroke, is levodopa more effective than placebo, when given before physiotherapy sessions, for enhancing motor recovery?


Randomised (unclear allocation concealment*), blinded (participants, healthcare providers, and outcome assessors),* placebo controlled trial with 6 weeks of follow up.


A rehabilitation hospital in Germany.


53 patients who had a stroke 3 weeks to 6 months before randomisation and a radiologically verified thromboembolic brain infarction. Exclusion criteria were depression according to Diagnostic Statistical Manual IV criteria or treatment with selective serotonin reuptake inhibitors or tricyclic antidepressants. 47 patients (89%) (mean age 62 y, 55% men) were included in the analysis.


Patients were allocated to levodopa, 100 mg, plus carbidopa (n=26) or …

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  • * See glossary.

  • For correspondence: Dr K Scheidtmann, Neurologische Klinik, Bad Aibling, Germany. Kscheidtmann{at}

  • Source of funding: in part, DuPont Pharma, Germany.