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  • Review: thrombolysis increases short term death and intracranial haemorrhage but decreases long term death or dependence

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Therapeutics
Review: thrombolysis increases short term death and intracranial haemorrhage but decreases long term death or dependence

https://doi.org/10.1136/ebm.7.2.48

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    (2001) Neurology 57, S69; Wardlaw JM.. Overview of Cochrane thrombolysis meta-analysis.. Sep;. (Suppl 2):. –76.
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    (2001) Cochrane Database Syst Rev 4, CD000213. Wardlaw JM, del Zoppo G, Yamaguchi T.. Thrombolysis for acute ischaemic stroke.. ;(. ):. (latest version 24 Jul 2001)..
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 QUESTION: In patients with acute ischaemic stroke, is thrombolytic treatment safe and effective for reducing mortality and intracranial haemorrhage, and for improving functional outcome?

    Data sources

    Studies were identified by searching the Cochrane Specialised Register of Controlled Trials and EMBASE/Excerpta Medica, hand searching neurological and stroke journals, writing to 321 pharmaceutical companies for information, and reviewing meeting abstracts and conference proceedings.

    Study selection

    Studies were selected if they were randomised controlled trials that compared thrombolytic drugs with placebo or control treatment in patients with definite acute ischaemic stroke. Trials were excluded if the treatment or control group received another active treatment not factored into the randomisation.

    Data extraction

    Data were extracted on patients, drug dose, administration route, duration of treatment, stroke type, results of computed tomography, and duration of follow up. Outcomes were all-cause mortality 7 to 10 days after treatment, symptomatic or fatal …

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    Footnotes

    • For correspondence: Professor J M Wardlaw, Western General Hospital, Edinburgh, Scotland, UK. jmw{at}skull.dcn.ed.ac.uk.

    • Source of funding: no external funding.