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  • B-natriuretic peptide concentrations had high sensitivity and specificity for detecting abnormal ventricular function

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Diagnosis
B-natriuretic peptide concentrations had high sensitivity and specificity for detecting abnormal ventricular function

https://doi.org/10.1136/ebm.7.2.59

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    (2001) Am J Med 111, 274. Krishnaswamy P, Lubien E, Clopton P. , et al. . Utility of B-natriuretic peptide levels in identifying patients with left ventricular systolic or diastolic dysfunction.. Sep;. :. –9.
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 QUESTION: In patients referred for echocardiography, what are the diagnostic properties of B-natriuretic peptide (BNP) concentrations for detecting abnormal ventricular function?

    Design

    Blinded comparison of BNP concentration with the results of echocardiography as the diagnostic standard.

    Setting

    San Diego Veteran's Healthcare System, California, USA.

    Patients

    400 patients (mean age 67 y, 96% men) who were referred for echocardiography to evaluate left ventricular function. Patients whose referral was to assess valve disease or to rule out vegetation or cardioembolic stroke were excluded.

    Description of test and diagnostic standard

    The BNP concentration in blood samples from all patients was measured using the Triage B-type natriuretic fluorescence immunoassay (Biosite Diagnostics, La Jolla, CA, USA). All patients were scanned with 2-dimensional echocardiography using commercially available instruments that operate at 2.0 to 3.5 mHz; the scans were done in standard fashion …

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    Footnotes

    • Source of funding: no external funding.

    • For correspondence: Dr A S Maisel, VAMC Cardiology 111-A, San Diego, CA, USA. amaisel{at}ucsd.edu.