Article Text

Download PDFPDF
B-natriuretic peptide concentrations had high sensitivity and specificity for detecting abnormal ventricular function

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

 QUESTION: In patients referred for echocardiography, what are the diagnostic properties of B-natriuretic peptide (BNP) concentrations for detecting abnormal ventricular function?


Blinded comparison of BNP concentration with the results of echocardiography as the diagnostic standard.


San Diego Veteran's Healthcare System, California, USA.


400 patients (mean age 67 y, 96% men) who were referred for echocardiography to evaluate left ventricular function. Patients whose referral was to assess valve disease or to rule out vegetation or cardioembolic stroke were excluded.

Description of test and diagnostic standard

The BNP concentration in blood samples from all patients was measured using the Triage B-type natriuretic fluorescence immunoassay (Biosite Diagnostics, La Jolla, CA, USA). All patients were scanned with 2-dimensional echocardiography using commercially available instruments that operate at 2.0 to 3.5 mHz; the scans were done in standard fashion …

View Full Text


  • Source of funding: no external funding.

  • For correspondence: Dr A S Maisel, VAMC Cardiology 111-A, San Diego, CA, USA. amaisel{at}