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Overall satisfaction increased more with inhaled insulin than with subcutaneous insulin in type 1 diabetes

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 QUESTION: In patients with type 1 diabetes mellitus, is patient satisfaction greater with inhaled insulin use than with subcutaneous insulin injection?


Randomised {allocation concealed*}, unblinded,* controlled trial with 12 weeks of follow up.


10 centres in the US.


{72 patients} who were 18 to 55 years of age and were following a stable insulin administration schedule of 2 to 3 daily injections for ≥ 2 months. Other inclusion criteria were screening and pre-randomisation glycated haemoglobin values between 7.0% and 11.9%, fasting plasma C peptide concentration ≤ 0.2 pmol/ml, body weight 80% to 130% of ideal, non-smoking for ≥ 6 months, normal results on chest x ray and pulmonary function tests, and normal sinus rhythm (rate 50 to 100 beats/min). 69 patients (96%) (mean age 37 y, 54% men, 80% white) were considered for analysis.


35 patients were allocated to receive preprandial inhaled insulin immediately before …

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  • * See glossary.

  • Information provided by author.

  • Source of funding: Pfizer Inc.

  • For correspondence: Dr R A Gerber, Pfizer Inc, Groton, CT, USA. robert_a_gerber{at}