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QUESTION: What is the effectiveness of vaccines in preventing influenza in healthy adults?
Studies were identified by searching Medline (1966–97) with the terms influenza, route (oral), route (parenteral), and vaccine; searching EMBASE/Excerpta Medica (1990–97) and the Cochrane Controlled Trials Register; handsearching the journal Vaccine to 1997; scanning the bibliographies of articles; and contacting manufacturers of vaccines and authors of studies in the review.
Studies were selected if they were quasi-randomised or randomised controlled trials (RCTs) that compared influenza vaccines with placebo, control vaccines, or no intervention or doses or schedules of influenza vaccine in healthy people 14 to 60 years of age and that assessed protection from exposure to naturally occurring influenza.
Data were extracted on study …
Source of funding: Ministry of Defence, UK.
For correspondence: Dr V Demicheli, Servizio Sovrazonale di Epidemiologia, Alessandria, Piemonte, Italy..