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Therapeutics
Lansoprazole provided more effective and faster relief for heartburn than omeprazole in erosive oesophagitis

https://doi.org/10.1136/ebm.7.3.85

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    (2001) Am J Gastroenterol 96, 3089. Richter JE, Kahrilas PJ, Sontag SJ, et al.. Comparing lansoprazole and omeprazole in onset of heartburn relief: results of a randomized, controlled trial in erosive esophagitis patients.. Nov;. :. –98.
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 QUESTION: In patients with erosive oesophagitis, is lansoprazole better than omeprazole for relieving heartburn?

    Design

    Randomised {allocation concealed*}†, blinded {patients, clinicians, data collectors, outcome assessors, and data safety and monitoring committee}†,* controlled trial with 8 week follow up.

    Setting

    162 clinical centres in the USA.

    Patients

    3510 patients who were ≥ 18 years of age (mean age 47y, 57% men), had endoscopically confirmed erosive oesophagitis ≥ grade 2, and had had ≥ 1 episode of moderate to very severe heartburn during the previous 3 days or nights, or both. Exclusion criteria included duodenal or gastric ulcers ≥ 3 mm in diameter; systemic disease affecting the oesophagus; history of gastrointestinal bleeding or gastric, duodenal, or oesophageal surgery; and long term use of ulcerogenic drugs. 96% of patients completed the study. …

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    Footnotes

    • ↵* See glossary.

    • ↵† Information provided by author.

    • Source of funding: TAP Pharmaceutical Products.

    • For correspondence: Dr J E Richter, Cleveland Clinic Foundation, Cleveland, Ohio, USA. richtej{at}ccf.org.