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Lansoprazole provided more effective and faster relief for heartburn than omeprazole in erosive oesophagitis

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 QUESTION: In patients with erosive oesophagitis, is lansoprazole better than omeprazole for relieving heartburn?


Randomised {allocation concealed*}, blinded {patients, clinicians, data collectors, outcome assessors, and data safety and monitoring committee},* controlled trial with 8 week follow up.


162 clinical centres in the USA.


3510 patients who were ≥ 18 years of age (mean age 47y, 57% men), had endoscopically confirmed erosive oesophagitis ≥ grade 2, and had had ≥ 1 episode of moderate to very severe heartburn during the previous 3 days or nights, or both. Exclusion criteria included duodenal or gastric ulcers ≥ 3 mm in diameter; systemic disease affecting the oesophagus; history of gastrointestinal bleeding or gastric, duodenal, or oesophageal surgery; and long term use of ulcerogenic drugs. 96% of patients completed the study. …

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  • * See glossary.

  • Information provided by author.

  • Source of funding: TAP Pharmaceutical Products.

  • For correspondence: Dr J E Richter, Cleveland Clinic Foundation, Cleveland, Ohio, USA. richtej{at}