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QUESTION: In patients with erosive oesophagitis, is lansoprazole better than omeprazole for relieving heartburn?
Design
Randomised {allocation concealed*}†, blinded {patients, clinicians, data collectors, outcome assessors, and data safety and monitoring committee}†,* controlled trial with 8 week follow up.
Setting
162 clinical centres in the USA.
Patients
3510 patients who were ≥ 18 years of age (mean age 47y, 57% men), had endoscopically confirmed erosive oesophagitis ≥ grade 2, and had had ≥ 1 episode of moderate to very severe heartburn during the previous 3 days or nights, or both. Exclusion criteria included duodenal or gastric ulcers ≥ 3 mm in diameter; systemic disease affecting the oesophagus; history of gastrointestinal bleeding or gastric, duodenal, or oesophageal surgery; and long term use of ulcerogenic drugs. 96% of patients completed the study. …