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  • Oral dexamethasone led to fewer treatment failures than did nebulised dexamethasone or placebo in children with mild croup

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Therapeutics
Oral dexamethasone led to fewer treatment failures than did nebulised dexamethasone or placebo in children with mild croup

https://doi.org/10.1136/ebm.7.4.113

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    (2001) Arch Pediatr Adolesc Med 155, 1340; Luria JW, Gonzalez-del-Rey JA, DiGiulio GA, et al.. Effectiveness of oral or nebulized dexamethasone for children with mild croup.. Dec;. :. –5.
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 QUESTION: In children with mild croup, does oral dexamethasone decrease the need for subsequent treatments and care and shorten symptom duration more than nebulised dexamethasone or placebo?

    Design

    Randomised (allocation concealed*), blinded {patients, clinicians, outcome assessors, and data collectors}†,* placebo controlled trial with 7 days of follow up.

    Setting

    Emergency departments at 2 large urban tertiary care centres in Ohio, USA.

    Patients

    264 children between 6 months and 6 years of age (mean age 28 mo, 68% boys) who had symptoms of croup for < 48 hours. Exclusion criteria were severe disease, receipt of racemic epinephrine or corticosteroid treatment, spasmodic croup, or a history of prolonged endotracheal intubation or chronic respiratory illness. 84% of patients were assessed at day 7.

    Intervention

    Children were allocated to oral dexamethasone, 0.6 mg/kg of …

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