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Growth rate was greater with fluticasone propionate than with beclomethasone dipropionate in children with chronic asthma

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 QUESTION: In children with chronic asthma, what are the effects of fluticasone propionate compared with those of beclomethasone dipropionate on growth rates?


Randomised (allocation concealed*), blinded (unclear),* controlled trial with 12 months of follow up.


32 centres in 7 countries: The Netherlands, Hungary, Italy, Poland, Argentina, Chile, and South Africa.


343 children who were 4 to 11 years of age (mean age 8y, 72% boys); had a sexual maturity rating of Tanner stage 1; required treatment with fluticasone propionate, 100 to 200 μg/day, or beclomethasone dipropionate or budesonide, 200 to 500 μg/day, for ≥ 8 weeks before study entry at a constant dosage for ≥ 4 weeks before the run-in period; had a mean morning peak expiratory flow rate (PEFR) during the last 7 days of the run-in period of ≤ 85% of their maximum achievable response after using a metered dose inhaler containing albuterol sulphate, 400 μg; and had an asthma symptom score ≥ …

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  • Source of funding: GlaxoSmithKline, Uxbridge, UK.

  • For correspondence: Dr F M de Benedictis, Clinica Pediatrica, Policlinico Monteluce, Perugia, Italy. debened{at}

  • * See glossary.