You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Sildenafil improved erectile dysfunction and quality of life in men with comorbid mild to moderate depression

https://doi.org/10.1136/ebm.7.4.121

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (2001) Am J Psychiatry 158, 1623; Seidman SN, Roose SP, Menza MA, et al.. Treatment of erectile dysfunction in men with depressive symptoms: results of a placebo-controlled trial with sildenafil citrate.. Oct;. :. –30.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 QUESTION: In men with erectile dysfunction (ED) and mild-to-moderate depression, does depression affect ED treatment response to sildenafil and does improvement in ED affect depression?

    Design

    Randomised {allocation concealed*}†, blinded {patients, clinicians, data collectors, and outcome assessors}†,* placebo controlled trial with 12 weeks of follow up.

    Setting

    20 urology clinics in the USA.

    Patients

    152 men (mean age 56 y) who had ED for ≥ 6 months (mean duration 6 y); a stable relationship with a female partner for ≥ 6 months; a Diagnostic and Statistical Manual of Mental Disorders, 4th ed, diagnosis of depressive disorder not otherwise specified; and a Hamilton Depression Rating Scale score of ≥ 12. Exclusion criteria included presence of another axis I psychiatric disorder, current use of nitrates or any antidepressant medication, and abnormal serum hormone concentrations. 89% of patients were included in the analysis.

    Intervention

    74 men were …

    View Full Text

    Footnotes

    • Source of funding: Pfizer Inc.

    • For correspondence: Dr S N Seidman, Columbia University, New York, USA. sns5{at}columbia.edu.

    • ↵* See glossary.

    • ↵† Information provided by author.

    • ↵‡ p Value calculated from data in article.