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Sildenafil improved erectile dysfunction and quality of life in men with comorbid mild to moderate depression

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 QUESTION: In men with erectile dysfunction (ED) and mild-to-moderate depression, does depression affect ED treatment response to sildenafil and does improvement in ED affect depression?


Randomised {allocation concealed*}, blinded {patients, clinicians, data collectors, and outcome assessors},* placebo controlled trial with 12 weeks of follow up.


20 urology clinics in the USA.


152 men (mean age 56 y) who had ED for ≥ 6 months (mean duration 6 y); a stable relationship with a female partner for ≥ 6 months; a Diagnostic and Statistical Manual of Mental Disorders, 4th ed, diagnosis of depressive disorder not otherwise specified; and a Hamilton Depression Rating Scale score of ≥ 12. Exclusion criteria included presence of another axis I psychiatric disorder, current use of nitrates or any antidepressant medication, and abnormal serum hormone concentrations. 89% of patients were included in the analysis.


74 men were …

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  • Source of funding: Pfizer Inc.

  • For correspondence: Dr S N Seidman, Columbia University, New York, USA. sns5{at}

  • * See glossary.

  • Information provided by author.

  • p Value calculated from data in article.