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QUESTION: In patients with HIV who are receiving highly active antiretroviral therapy (HAART), does a scoring system predict clinical progression?
Prognostic scoring system developed in 1 derivation cohort and validated in 2 cohorts of patients.
60 centres in Europe and Israel.
2027 patients (median age 37 y) formed the derivation set: inception cohort of participants in the EuroSIDA study who were ≥ 16 years of age and had started a protease inhibitor or non-nucleoside reverse-transcriptase inhibitor as part of a HAART antiretroviral regimen and had CD4 cell counts and viral loads measured within 6 months before starting HAART and ≥ 1 measurement after starting HAART. 2 cohorts of patients formed the validation set: 1946 patients in the EuroSIDA study who started HAART before recruitment to the study and 1442 patients from a clinic in Barcelona who had previously started HAART.
Description of prediction guide
Cox proportional hazards models were used to determine factors associated with clinical progression. The final prediction model comprised …