Therapeutics
Review: selegiline leads to a small short term improvement in cognition and activities of daily living in Alzheimer’s disease
Wilcock GK, Birks J, Whitehead A, et al. The effect of selegiline in the treatment of people with Alzheimer’s disease: a meta-analysis of published trials. Int J Geriatr Psychiatry 2002 Feb;17:175–83.
Abciximab added to urokinase increased amputation-free survival in peripheral arterial occlusion of the legs
Duda SH, Tepe G, Luz O, et al. Peripheral artery occlusion: treatment with abciximab plus urokinase versus with urokinase alone: a randomized pilot trial (the PROMPT Study). Radiology 2001 Dec;221:689–96.
Review: interferon α plus ribavirin improves the virologic response in chronic hepatitis C
Kjaergard LL, Krogsgaard K, Gluud C. Interferon alfa with or without ribavirin for chronic hepatitis C: systematic review of randomised trials. BMJ 2001 Nov 17;323:1151–5.
The inactivated trivalent split virus influenza vaccine was safe in stable asthma
American Lung Association Asthma Clinical Research Centers. The safety of inactivated influenza vaccine in adults and children with asthma. N Engl J Med 2001 Nov 22;345:1529–36.
Review: extended out of hospital prophylaxis with heparin prevents deep venous thrombosis in elective hip arthroplasty
Hull RD, Pineo GF, Stein PD, et al. Extended out-of-hospital low-molecular-weight heparin prophylaxis against deep venous thrombosis in patients after elective hip arthroplasty: a systematic review. Ann Intern Med 2001 Nov 20;135:858–69.
Review: bed rest does not prevent cervical or lumbar puncture headaches
Thoennissen J, Herkner H, Lang W, et al. Does bed rest after cervical or lumbar puncture prevent headache? A systematic review and meta-analysis. CMAJ 2001 Nov 13;165:1311–6.
An early invasive strategy was effective in the acute coronary syndrome with elevated cardiac troponin I and T levels
Morrow DA, Cannon CP, Rifai N, et al, for the TACTICS-TIMI 18 Investigators. Ability of minor elevations of troponins I and T to predict benefit from an early invasive strategy in patients with unstable angina and non-ST elevation myocardial infarction: results from a randomized trial. JAMA 2001 Nov 21;286:2405–12.
Review: St. John’s wort, gingko, saw palmetto, and kava may be effective for some conditions
Ernst E. The risk-benefit profile of commonly used herbal therapies: ginkgo, St. John’s wort, ginseng, echinacea, saw palmetto, and kava. Ann Intern Med 2002 Jan 1;136:42–53.
Helicobacter pylori eradication reduced the risk for ulcers in dyspeptic patients who were about to begin NSAID treatment
Chan FK, To KF, Wu JC, et al. Eradication of Helicobacter pylori and risk of peptic ulcers in patients starting long-term treatment with non-steroidal anti-inflammatory drugs: a randomised trial. Lancet 2002 Jan 5;359:9–13.
Montelukast improved pulmonary function and asthma specific quality of life in aspirin intolerant asthma
Dahlén SE, Malmström K, Nizankowska E, et al. Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial. Am J Respir Crit Care Med 2002 Jan 1;165:9–14.
Review: hospital at home care for early discharge or admission avoidance does not improve health outcomes
Shepperd S, Iliffe S. Hospital at home versus in-patient hospital care. Cochrane Database Syst Rev 2002;(2):CD000356 (latest version 15 Feb 2001).
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