Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
QUESTION: In overweight people with increased fasting and postload plasma glucose concentrations, does an intensive lifestyle intervention or treatment with metformin plus standard lifestyle recommendations prevent or delay the onset of type 2 diabetes mellitus?
Randomised (allocation concealed*), blinded (clinicians and participants for metformin and placebo),* placebo controlled trial with mean follow up of 2.8 years.
27 centres in the US.
3234 participants (mean age 51 y, 68% women) without diabetes who had a body mass index ≥24 (≥22 for Asians) and a plasma glucose concentration of 5.3 to 6.9 mmol/l in the fasting state and 7.8 to 11.0 mmol/l 2 hours after a 75 g oral glucose load. Exclusion criteria included medications known to alter glucose tolerance and illnesses that could seriously reduce life …