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  • Review: n-3 polyunsaturated fatty acids reduce fatal myocardial infarction, sudden death, and overall mortality in coronary artery disease

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Therapeutics
Review: n-3 polyunsaturated fatty acids reduce fatal myocardial infarction, sudden death, and overall mortality in coronary artery disease

https://doi.org/10.1136/ebm.7.5.142

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    (2002) Am J Med 112, 298; Bucher HC, Hengstler P, Schindler C, et al.. N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials.. Mar;. :. –304.
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 QUESTION: In patients with coronary artery disease (CAD), is dietary or supplemental intake of n-3 polyunsaturated fatty acids more effective than a control diet or placebo for reducing fatal and non-fatal myocardial infarction (MI) and overall mortality?

    Data sources

    Studies in any language were identified by searching Medline, EMBASE/Excerpta Medica, Pascal BioMed, and Index Medicus from 1966 to August 1999; by searching the Cochrane Library; and by scanning bibliographies of relevant publications.

    Study selection

    Studies were selected if they were randomised controlled trials (RCTs) that compared dietary or supplemental intake of n-3 polyunsaturated fatty acids with a control diet or placebo, reported fatal or non-fatal MI and overall mortality, and followed patients with MI or angiographically established CAD for ≥ 6 months. Studies with …

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    Footnotes

    • Sources of funding: University of Basel Hospitals; Byk AG; Semomed AG, Switzerland.

    • For correspondence: Dr H C Bucher, Institut für Klinische Epidemiologie, Kantonsspital Basel, Basel, Switzerland.hbucher{at}uhbs.ch.