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Therapeutics
Review: nedocromil sodium decreases airflow reduction and recovery time in exercise induced bronchoconstriction

https://doi.org/10.1136/ebm.7.5.145

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    ; Spooner CH, Saunders LD, Rowe BH.Nedocromil sodium for preventing exercise-induced bronchoconstriction. Cochrane Database Syst Rev 2002(2):CD:001183 (latest version 20 Sep 2001)..

    
 
 QUESTION: In patients with exercise induced bronchoconstriction (EIB), is nedocromil sodium effective for reducing the severity and duration of symptoms?

    Data sources

    Studies were identified by searching the Cochrane Airways Group trial register; the Cochrane Controlled Trials Register; Current Contents; and bibliographies of relevant studies, review articles, and textbooks. The manufacturer of nedocromil sodium (Rhône-Poulenc Rorer) and study authors were contacted.

    Study selection

    2 reviewers independently selected studies if they were randomised, double blind, controlled trials; any dose of inhaled nedocromil sodium was compared with placebo before exercise; and patients had a history of EIB or showed evidence of EIB (reduction of FEV1 or peak expiratory flow rate [PEFR] ≥ 10%) in an exercise challenge before study entry. Studies using delivery by nasal spray were excluded.

    Data extraction

    2 reviewers independently assessed the quality of studies and extracted data on patients, interventions, and outcomes (mean maximum …

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    Footnotes

    • Source of funding: Institute of Health Economics, Alberta, Canada.

    • For correspondence: Mrs C Spooner, University of Alberta, Edmonton, Alberta, Canada. cspooner{at}ualberta.ca