Article Text

Download PDFPDF

Review: tricyclic antidepressants, capsaicin, gabapentin, and oxycodone are effective for postherpetic neuralgia

Statistics from

 QUESTION: In patients with postherpetic neuralgia (PHN), are any treatments effective in reducing pain or disability?

Data sources

Studies were identified by searching Medline (1966 to October 2000) and the Cochrane Controlled Trials Registry with the terms postherpetic neuralgia, neuropathy, and pain; searching Current Contents, bibliographies of relevant studies, and the US Food and Drug Administration web site; and contacting authors and content experts.

Study selection

English language studies were selected if they were full reports of randomised controlled trials that included patients with PHN (history of herpes zoster, pain in the dermatomal distribution of the zoster rash, and pain persisting after resolution of the rash) and addressed relevant outcomes (pain resolution, pain severity, or quality of life).

Data extraction

2 reviewers independently reviewed trials for quality and extracted data on patient age and duration of PHN, type of treatment, treatment dosage and duration, results, and adverse effects.

Main results

27 trials were included. 6 trials evaluated topical treatments (follow up of 2 d to 6 wk). Of 2 trials that compared a lidocaine patch with placebo, 1 showed no difference and 1 showed …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.