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Clonidine and methylphenidate were effective for attention deficit hyperactivity disorder in children with comorbid tics

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 QUESTION: In children with attention deficit hyperactivity disorder (ADHD) and Tourette’s syndrome (TS), what is the effect of clonidine (CLON), methylphenidate (MPH), or combined CLON and MPH?


Randomised (allocation concealed*), blinded {patients, clinicians, data collectors, outcome assessors, data analysts, data safety and monitoring committee, and manuscript writers}*, placebo controlled trial with 16 weeks of follow up.


11 sites in the US.


136 children between 7 and 14 years of age (mean age 10 y, 85% boys) who had ADHD of any subtype and TS, chronic motor tic disorder, or chronic vocal tic disorder. Exclusion criteria included secondary tic disorder, major depression, pervasive developmental disorder, autism, mental retardation, anorexia nervosa, and bulimia. Follow up was 86%.


Children were allocated to receive CLON alone (n=34), MPH alone (n=37), combined CLON and MPH (n=33), or placebo (n=32). …

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  • Sources of funding: National Institutes of Health; Tourette Syndrome Association.

  • For correspondence: Dr R Kurlan, University of Rochester Medical Center, Rochester, New York, USA. roger_kurlan{at}

  • Abstract and commentary also appear in Evidence-Based Mental Health.

  • * See glossary.

  • Information provided by author.