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Aetiology
Increased plasma total homocysteine levels increased the risk for dementia in the elderly

https://doi.org/10.1136/ebm.7.5.160

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    (2002) N Engl J Med 346, 476; Seshadri S, Beiser A, Selhub J, et al.. Plasma homocysteine as a risk factor for dementia and Alzheimer’s disease.. Feb 14;. :. –83.
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 QUESTION: Is an increased plasma total homocysteine concentration a risk factor for dementia in the elderly?

    Design

    Cohort study with a median follow up of 8 years.

    Setting

    Framingham, Massachusetts, USA.

    Participants

    1092 elderly participants (mean age 76 y, 61% women) from the Framingham Study cohort who were free from dementia and had plasma total homocysteine levels measured at their 20th biennial examination.

    Assessment of risk factors

    Baseline data were collected on the plasma total homocysteine level. Analyses were adjusted for baseline age; sex; apolipoprotein E genotype (93% of participants); plasma levels of folate (98% of participants), vitamin B-12 (85% of participants), and vitamin B-6 (92% of participants); educational status; history of stroke; cigarette smoking; alcohol intake; diabetes mellitus; systolic blood pressure; and body mass index.

    Main outcome measures

    Dementia (Diagnostic and Statistical Manual of Mental Disorders, 4th edition, …

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    • Correction
      Correction
      BMJ Publishing Group Ltd
      BMJ Evidence-Based Medicine 2002; 7 167-167 Published Online First: 01 Nov 2002. doi: 10.1136/ebm.7.6.167