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  • Effects of hormone therapy on quality of life in postmenopausal women with CAD differed according to menopausal symptoms

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Therapeutics
Effects of hormone therapy on quality of life in postmenopausal women with CAD differed according to menopausal symptoms

https://doi.org/10.1136/ebm.7.6.171

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    (2002) JAMA 287, 591; Hlatky MA, Boothroyd D, Vittinghoff E, et al, for the HERS Research Group.. Quality of life and depressive symptoms in postmenopausal women after receiving hormone therapy: results from the Heart and Estrogen/Progestin Replacement Study (HERS) trial.. Feb 6;. :. –7.
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 QUESTION: Does hormone therapy (HT) improve health-related quality of life (HRQL) in postmenopausal women with coronary artery disease (CAD)?

    Design

    Randomised {allocation concealed*}†, blinded {patients, clinicians, data collectors, and outcome assessors}‡*, placebo-controlled trial with follow up to 3 years.

    Setting

    Outpatient and community settings at 20 US clinical centres.

    Patients

    2763 postmenopausal women <80 years of age (mean age 67 y) with documented CAD (previous myocardial infarction [MI], >50% luminal narrowing of a major vessel on angiography, or a previous coronary revascularisation procedure). Exclusion criteria were MI or revascularisation procedure in the past 6 months, previous hysterectomy, contraindications to HT, HT in the previous 3 months, or life-threatening illness. 2762 patients (99.9%) were included in the analysis; 2246 (81%) had HRQL data for all time points (baseline, 4 mo, 1 y, and 3 y).

    Intervention

    1380 women were allocated to HT (0.625 mg of conjugated equine oestrogens and 2.5 mg of medroxyprogesterone acetate [Prempro, …

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