Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
QUESTION: In patients with essential hypertension and signs of left ventricular hypertrophy (LVH), is losartan-based therapy more effective than atenolol-based therapy?
Randomised (unclear allocation concealment*), blinded (patients and monitoring committee),* controlled trial with ≥4 years follow-up.
Multicentre trial in Europe and the United States.
9222 patients 55 to 80 years of age (mean age 67 y, 54% women) with hypertension (sitting blood pressure [BP] after 1 to 2 wks of placebo of 160 to 200 mm Hg systolic, 95 to 115 mm Hg diastolic, or both) and electrocardiographical signs of LVH. Exclusion criteria included secondary hypertension; myocardial infarction (MI) or stroke within the previous 6 months; angina pectoris requiring treatment with β-blockers or calcium antagonists; and heart failure or left ventricular ejection fraction ≤40%. Follow-up was 99%.
Patients were allocated to losartan based therapy (n = 4605) or atenolol based therapy (n = 4588). Losartan and atenolol were started at 50 mg/day, combined with low dose hydrochlorothiazide if needed and …