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QUESTION: In patients with probable vascular dementia or Alzheimer’s disease (AD) with cerebrovascular disease, is galantamine more effective than placebo for improving cognitive ability and global functioning?
6 month randomised (unclear allocation concealment*), blinded (clinicians and patients),* placebo-controlled trial.
Canada, Denmark, Finland, France, Germany, Ireland, Israel, The Netherlands, Poland, and the UK.
592 patients (mean age 75 y, 53% men) who met clinical criteria for probable vascular dementia or possible AD with radiological evidence of cerebrovascular disease. Additional inclusion criteria included a score of 10 to 25 on the Mini-Mental State Examination and ≥12 on the Alzheimer Disease Assessment Scale Cognitive subscale (ADAS-COG). Exclusion criteria included evidence of neurodegenerative disorders other than AD that might cause or contribute to dementia, and cognitive …