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Ibuprofen was more protective against asthma morbidity than acetaminophen in asthmatic children with fever

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 QUESTION: In asthmatic children with a febrile illness, does ibuprofen increase asthma morbidity more than acetaminophen?

Design

Subgroup analysis of a randomised {allocation concealed*}, blinded (clinicians, patients, and {outcome assessors}),* controlled trial with 1 month follow up (Boston University Fever Study).

Setting

Pediatric practices throughout the United States.

Patients

1879 children between 6 months and 12 years of age (median age 46 mo, 62% boys) who were being treated for asthma with a β-agonist, theophylline, or inhaled steroid and had a febrile illness. Exclusion criteria were known sensitivity to acetaminophen, ibuprofen, aspirin, or any non-steroidal anti-inflammatory drug (NSAID); nasal polyps; angioedema; or bronchospastic reactivity to aspirin or other NSAIDs. Follow up was complete.

Intervention

Patients were allocated to suspensions of …

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Footnotes

  • Sources of funding: McNeil Consumer Healthcare Company and Boots Healthcare International.

  • For correspondence: Dr S M Lesko, Boston University School of Medicine, Boston, MA, USA. Email leskos{at}bu.edu.

  • * See glossary.

  • Information provided by author.