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Therapeutics
Ibuprofen was more protective against asthma morbidity than acetaminophen in asthmatic children with fever

https://doi.org/10.1136/ebm.7.6.182

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    (2002) Pediatrics 109, e20; Lesko SM, Louik C, Vezina RM, Mitchell AA.. Asthma morbidity after the short-term use of ibuprofen in children.. Feb;. :. ..
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 QUESTION: In asthmatic children with a febrile illness, does ibuprofen increase asthma morbidity more than acetaminophen?

    Design

    Subgroup analysis of a randomised {allocation concealed*}†, blinded (clinicians, patients, and {outcome assessors}†),* controlled trial with 1 month follow up (Boston University Fever Study).

    Setting

    Pediatric practices throughout the United States.

    Patients

    1879 children between 6 months and 12 years of age (median age 46 mo, 62% boys) who were being treated for asthma with a β-agonist, theophylline, or inhaled steroid and had a febrile illness. Exclusion criteria were known sensitivity to acetaminophen, ibuprofen, aspirin, or any non-steroidal anti-inflammatory drug (NSAID); nasal polyps; angioedema; or bronchospastic reactivity to aspirin or other NSAIDs. Follow up was complete.

    Intervention

    Patients were allocated to suspensions of …

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