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Review: infliximab increases response and remission rates in fistulising or treatment-resistant Crohn’s disease

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 QUESTION: In patients with fistulising or treatment-resistant Crohn’s disease, is infliximab safe and effective?

Data sources

Studies were identified by searching Medline, EMBASE/Excerpta Medica, Current Contents, CINAHL, HealthSTAR, TOXLINE, the Cochrane Library, Drug Info Full Text, Pharmaceutical & Health Care Industry News, PharmaProjects, and Pharmaceutical News Index (1990 to May 2001). Scientific meeting abstracts were searched; major clinical gastroenterology journals were hand searched (to August 2001); and authors, government agencies, and pharmaceutical companies were contacted.

Study selection

2 reviewers independently selected English-language randomised controlled trials (RCTs) that reported clinical end points for infliximab treatment in adults with fistulising or treatment-resistant Crohn’s disease.

Data extraction

2 independent reviewers extracted data on study centres, source of funding, …

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  • Source of funding: not stated.

  • For correspondence: Dr J K Marshall, McMaster University, Hamilton, ON, Canada. Email marshallj{at}