You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Lansoprazole reduced recurrence of ulcer complications in long term use of low dose aspirin

https://doi.org/10.1136/ebm.8.1.19

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (2002) N Engl J Med 346, 2033; Lai KC, Lam SK, Chu KM, et al.. Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use.. ;. :. –8.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 QUESTION: In patients receiving continuous treatment with low dose aspirin, is Helicobacter pylori eradication plus lansoprazole more effective than H pylori eradication alone for preventing the recurrence of ulcer complications?

    Design

    Randomised {allocation concealed*}†, blinded (clinicians, patients, outcome assessors, monitoring committee, and data analysts),* placebo controlled trial with a median follow up of 12 months.

    Setting

    A university hospital in Hong Kong, China.

    Patients

    123 patients who were 18–80 years of age (mean age 70 y, 72% men) and had ulcers (gastric, duodenal, or gastroduodenal), were receiving low dose aspirin for >1 month before developing ulcers, had a disease such as stroke or ischaemic heart disease that required long term continuous treatment with low dose aspirin, and had H pylori infection …

    View Full Text

    Footnotes

    • Source of funding: Peptic Ulcer Research Fund of the University of Hong Kong.

    • For correspondence: Dr K C Lai, Queen Mary Hospital, Hong Kong, China. kclai{at}hku.hk

    • Abstract and commentary also published in ACP Journal Club

    • ↵* See glossary.

    • ↵† Information provided by author.