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QUESTION: In patients receiving continuous treatment with low dose aspirin, is Helicobacter pylori eradication plus lansoprazole more effective than H pylori eradication alone for preventing the recurrence of ulcer complications?
Design
Randomised {allocation concealed*}†, blinded (clinicians, patients, outcome assessors, monitoring committee, and data analysts),* placebo controlled trial with a median follow up of 12 months.
Setting
A university hospital in Hong Kong, China.
Patients
123 patients who were 18–80 years of age (mean age 70 y, 72% men) and had ulcers (gastric, duodenal, or gastroduodenal), were receiving low dose aspirin for >1 month before developing ulcers, had a disease such as stroke or ischaemic heart disease that required long term continuous treatment with low dose aspirin, and had H pylori infection …
Footnotes
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Source of funding: Peptic Ulcer Research Fund of the University of Hong Kong.
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For correspondence: Dr K C Lai, Queen Mary Hospital, Hong Kong, China. kclai{at}hku.hk
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Abstract and commentary also published in ACP Journal Club
↵† Information provided by author.