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Lansoprazole reduced recurrence of ulcer complications in long term use of low dose aspirin

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 QUESTION: In patients receiving continuous treatment with low dose aspirin, is Helicobacter pylori eradication plus lansoprazole more effective than H pylori eradication alone for preventing the recurrence of ulcer complications?


Randomised {allocation concealed*}, blinded (clinicians, patients, outcome assessors, monitoring committee, and data analysts),* placebo controlled trial with a median follow up of 12 months.


A university hospital in Hong Kong, China.


123 patients who were 18–80 years of age (mean age 70 y, 72% men) and had ulcers (gastric, duodenal, or gastroduodenal), were receiving low dose aspirin for >1 month before developing ulcers, had a disease such as stroke or ischaemic heart disease that required long term continuous treatment with low dose aspirin, and had H pylori infection …

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  • Source of funding: Peptic Ulcer Research Fund of the University of Hong Kong.

  • For correspondence: Dr K C Lai, Queen Mary Hospital, Hong Kong, China. kclai{at}

  • Abstract and commentary also published in ACP Journal Club

  • * See glossary.

  • Information provided by author.