You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Magnesium sulphate prevented eclampsia in women with pre-eclampsia

https://doi.org/10.1136/ebm.8.1.9

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (2002) Lancet 359, 1877; The Magpie Trial Collaborative Group.. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. . ;. :. –90.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 QUESTION: In women with pre-eclampsia, does magnesium sulphate reduce the risk of eclampsia and improve pregnancy outcome?

    Design

    Randomised (allocation concealed*), blinded (clinicians, patients, data collectors, and data analysts),* placebo controlled trial with follow up to discharge from hospital after delivery (MAGnesium sulphate for Prevention of Eclampsia [MAGPIE] Trial).

    Setting

    175 hospitals in 33 countries.

    Patients

    10 141 women who had not yet given birth or had delivered within <24 hours, had pre-eclampsia (diastolic blood pressure [BP] ≥90 mm Hg, systolic BP ≥140 mm Hg on ≥2 occasions, and proteinuria ≥1+), and clinical uncertainty existed about the use of magnesium sulphate. Exclusion criteria were hypersensitivity to magnesium, hepatic coma with risk of renal failure, or myasthenia gravis. 99.7% of women were included in the analysis.

    Intervention

    Women were allocated to …

    View Full Text

    Footnotes

    • Sources of funding: UK Medical Research Council; UK Department for International Development; UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development, and Research Training in Human Reproduction.

    • For correspondence: Dr L Duley, Resource Centre for Randomised Trials, Oxford, UK. lelia.duley{at}ndm.ox.ac.uk

    • ↵* See glossary.