Article Text

Download PDFPDF

Magnesium sulphate prevented eclampsia in women with pre-eclampsia
Free

Statistics from Altmetric.com


 
 QUESTION: In women with pre-eclampsia, does magnesium sulphate reduce the risk of eclampsia and improve pregnancy outcome?

Design

Randomised (allocation concealed*), blinded (clinicians, patients, data collectors, and data analysts),* placebo controlled trial with follow up to discharge from hospital after delivery (MAGnesium sulphate for Prevention of Eclampsia [MAGPIE] Trial).

Setting

175 hospitals in 33 countries.

Patients

10 141 women who had not yet given birth or had delivered within <24 hours, had pre-eclampsia (diastolic blood pressure [BP] ≥90 mm Hg, systolic BP ≥140 mm Hg on ≥2 occasions, and proteinuria ≥1+), and clinical uncertainty existed about the use of magnesium sulphate. Exclusion criteria were hypersensitivity to magnesium, hepatic coma with risk of renal failure, or myasthenia gravis. 99.7% of women were included in the analysis.

Intervention

Women were allocated to …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.