Therapeutics
Prehospital fibrinolysis was as good as primary angioplasty after myocardial infarction
Bonnefoy E, Lapostolle F, Leizorovicz A,et al. Primary angioplasty versus prehospital fibrinolysis in acute myocardial infarction: a randomised study Lancet 2002;360:825–9.
An interventional strategy was better than a conservative strategy in unstable angina or non–ST-elevation MI
Fox KA, Poole-Wilson PA, Henderson RA,et al. Interventional versus conservative treatment for patients with unstable angina or non-ST-elevation myocardial infarction: the British Heart Foundation RITA 3 randomised trial. Lancet 2002;360:743–51.
Heparin plus alteplase reduced morbidity more than heparin alone in submassive pulmonary embolism
Konstantinides S, Geibel A, Heusel G,et al. Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism. N Engl J Med 2002;347:1143–50.
Review: β-blockers, sotalol, amiodarone, and biatrial pacing all reduce atrial fibrillation after heart surgery
Crystal E, Connolly SJ, Sleik K,et al. Interventions on prevention of postoperative atrial fibrillation in patients undergoing heart surgery. A meta-analysis. Circulation 2002;106:75–80.
Hydrocortisone and fludrocortisone improved 28-day survival in septic shock and adrenal insufficiency
Annane D, Sébille V, Charpentier C,et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288:862–71.
Review: β-lactam alone was better than β-lactam plus aminoglycoside for cancer patients with neutropenia
Paul M, Soares-Weiser K, Grozinsky S,et al. Beta-lactam versus beta-lactam-aminoglycoside combination therapy in cancer patients with neutropaenia. Cochrane Database Syst Rev 2002(2):CD003038(latest version 6 Jan 2002).
Review: antifungals absorbed or partially absorbed from the GI tract prevent oral candidiasis in cancer patients receiving treatment
Worthington HV, Clarkson JE, Eden OB. Interventions for preventing oral candidiasis for patients with cancer receiving treatment. Cochrane Database Syst Rev 2002;(3):CD003807 (latest version 10 Apr 2002).
Cervical spine manipulation was not better than mobilization for improving outcomes in neck pain
Hurwitz EL, Morgenstern H, Harber P,et al. A randomized trial of chiropractic manipulation and mobilization for patients with neck pain: clinical outcomes from the UCLA neck-pain study. Am J Public Health 2002;92:1634–41.
Review: tegaserod or alosetron are effective for the irritable bowel syndrome
Brandt LJ, Bjorkman D, Fennerty MB,et al. Systematic review on the management of irritable bowel syndrome in North America. Am J Gastroenterol 2002;97:S7–26.
Upper gastrointestinal event risk with COX-2 inhibitors depended on known risk factors
Laine L, Bombardier C, Hawkey CJ,et al. Stratifying the risk of NSAID-related upper gastrointestinal clinical events: results of a double-blind outcomes study in patients with rheumatoid arthritis. Gastroenterology 2002;123:1006–12.
Review: low dose was as effective as standard dose tricyclic antidepressants in adults with depression
Furukawa TA, McGuire H, Barbui C. Meta-analysis of effects and side effects of low dosage tricyclic antidepressants in depression: systematic review. BMJ 2002;325:991–5.
Prophylactic citalopram reduced recurrences of unipolar major depression
Klysner R, Bent-Hansen J, Hansen HL,et al. Efficacy of citalopram in the prevention of recurrent depression in elderly patients: placebo-controlled study of maintenance therapy. Br J Psychiatry 2002 ;181:29–35.
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