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Losartan was more effective than atenolol for isolated systolic hypertension and left ventricular hypertrophy

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 QUESTION: In patients with isolated systolic hypertension (ISH) and left ventricular hypertrophy (LVH), is losartan based therapy more effective than atenolol based therapy?


Randomised {allocation concealed*}, blinded {patients, clinicians, data collectors, outcome assessors, data analysts, and manuscript writers},* controlled trial with mean 4.7 year follow up.


945 outpatient settings in Europe and the US.


1326 patients between 55 and 80 years of age (mean age 70 y, 60% women) with ISH (sitting blood pressure [BP] 160–200 mm Hg systolic and <90 mm Hg diastolic after 1–2 wk of placebo) and electrocardiographic signs of LVH. …

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