You are here

Article Text

Article menu

Download PDFPDF

Therapeutics
Losartan was more effective than atenolol for isolated systolic hypertension and left ventricular hypertrophy
Free

https://doi.org/10.1136/ebm.8.2.43

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (2002) JAMA 288, 1491. Kjeldsen SE, Dahlöf B, Devereux RB, et al.. Effects of losartan on cardiovascular morbidity and mortality in patients with isolated systolic hypertension and left ventricular hypertrophy: a Losartan Intervention for Endpoint Reduction (LIFE) substudy.. ;. :. –8.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 QUESTION: In patients with isolated systolic hypertension (ISH) and left ventricular hypertrophy (LVH), is losartan based therapy more effective than atenolol based therapy?

    Design

    Randomised {allocation concealed*}†, blinded {patients, clinicians, data collectors, outcome assessors, data analysts, and manuscript writers}†,* controlled trial with mean 4.7 year follow up.

    Setting

    945 outpatient settings in Europe and the US.

    Patients

    1326 patients between 55 and 80 years of age (mean age 70 y, 60% women) with ISH (sitting blood pressure [BP] 160–200 mm Hg systolic and <90 mm Hg diastolic after 1–2 wk of placebo) and electrocardiographic signs of LVH. …

    View Full Text