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Therapeutics
Review: celecoxib is as effective as other NSAIDs and leads to fewer gastrointestinal adverse effects

http://dx.doi.org/10.1136/ebm.8.2.51

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    (2002) BMJ 325, 619. Deeks JJ, Smith LA, Bradley MD.. Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials.. ;. :. –23.
    OpenUrlAbstract/FREE Full Text

    
 
 QUESTION: In patients with osteoarthritis (OA) or rheumatoid arthritis (RA), is celecoxib as effective as other non-steroidal anti-inflammatory drugs (NSAIDs)? Does celecoxib have greater gastrointestinal (GI) safety than NSAIDs?

    Data sources

    Studies were identified by searching 3 electronic databases and by obtaining manufacturers’ reports of industry sponsored randomised controlled trials (RCTs).

    Study selection

    Studies were selected if they were double blind RCTs that compared celecoxib at a licensed therapeutic dose for ≥12 weeks with placebo or another NSAID in patients with active RA or OA.

    Data extraction

    1 reviewer extracted data from the original company trial reports. Multiple celecoxib treatment arms were combined for trials that randomised to ≥1 dose.

    Main results

    9 RCTS (15 187 patients) were included. 5 RCTs included a …

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    Footnotes

    • For correspondence: Dr J J Deeks, Institute of Health Sciences, Headington, Oxford, UK. jon.deeks{at}cancer.org.uk

    • Sources of funding: Pfizer and Searle.