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  • An Indo-Mediterranean diet was more effective than a control diet in primary and secondary coronary artery disease prevention

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Therapeutics
An Indo-Mediterranean diet was more effective than a control diet in primary and secondary coronary artery disease prevention

https://doi.org/10.1136/ebm.8.3.76

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    (2002) Lancet 360, 1455. Singh RB, Dubnov G, Niaz MA, et al.. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial.. ;. :. –61.
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 QUESTION: In patients with, or at high risk for, coronary artery disease (CAD), is an Indo-Mediterranean diet more effective than the conventional step 1 National Cholesterol Education Program (NCEP) prudent diet?

    Design

    Randomised (unclear allocation concealment*), blinded {clinicians, data collectors, and outcome assessors}†,* controlled trial with 2 years of follow up.

    Setting

    Moradabad, India.

    Patients

    1000 patients >25 years of age (mean age 48.5 y, 90% men) with angina pectoris, myocardial infarction, or ≥1 major risk factor for CAD, recruited through advertising. Exclusion criteria included cancer, long term diarrhoea or dysentery, blood urea nitrogen concentrations >6.6 mmol/l, and arthritis. Follow up was 98%.

    Intervention

    Participants were allocated to an Indo-Mediterranean diet (n=499) or a control diet similar to the step 1 NCEP prudent diet …

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    Footnotes

    • Source of funding: no external funding.

    • For correspondence: Professor E M Berry, Braun School of Public Health, and Hebrew University-Hadassah Medical School, Jerusalem, Israel. berry{at}md.huji.ac.il.

    • Abstract and commentary also appear in ACP Journal Club.

    • ↵* See glossary.

    • ↵† Information provided by author.