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Therapeutics
Review: terazosin improves urological symptoms in benign prostatic hyperplasia

https://doi.org/10.1136/ebm.8.3.83

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    (2002) Cochrane Database Syst Rev , CD003851. Wilt TJ, Howe RW, Rutks IR, et al.. Terazosin for benign prostatic hyperplasia.. ;. (4). :. (latest version 14 Sep 1999).

    
 
 QUESTION: In men with benign prostatic hyperplasia (BPH), does the non-uroselective α blocker terazosin improve urological symptoms?

    Data sources

    Studies were identified by searching Medline (1966–2001), the Cochrane Library, the Prostatic Diseases and Urologic Malignancies Group specialised register; and reviewing bibliographies of relevant studies and reviews.

    Study selection

    Studies were selected if they were randomised controlled trials (RCTs) in any language comparing terazosin with placebo, phytotherapy, or pharmacological or surgical therapies in men with symptomatic BPH and had a treatment duration ≥4 weeks.

    Data extraction

    2 reviewers independently extracted data on methodological quality, study design, patient characteristics, enrolment criteria, outcomes, adverse effects, and dropouts. The main outcome was change in urological symptoms measured by validated symptom scores (Boyarsky Symptom Score, American Urological Association [AUA], and International Prostate Symptom Score [IPSS]) (AUA and IPSS scales are identical), presented as the percentage absolute improvement from baseline. …

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    Footnotes

    • Source of funding: Department of Veterans Affairs Health Services Research and Development Service.

    • For correspondence: Dr T J Wilt, Minneapolis VA Center for Chronic Disease Outcomes Research, Minneapolis, MN, USA. Tim.Wilt{at}med.va.gov

    • Abstract and commentary also appear in ACP Journal Club.