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Therapeutics
Immediate antibiotics were beneficial in children with acute otitis media who had fever and vomiting

https://doi.org/10.1136/ebm.8.3.84

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    (2002) BMJ 325, 22. Little P, Gould C, Moore M, et al.. Predictors of poor outcome and benefits from antibiotics in children with acute otitis media: pragmatic randomised trial.. ;. :. –25.
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 QUESTION: In children with acute otitis media and who are at risk of a poor outcome, what is the comparative effectiveness of immediate and delayed antibiotics?

    Design

    Randomised {allocation concealed*}†, {unblinded}†,* trial with 3 days of follow up. This study was a secondary analysis of a previously published randomised controlled trial‡.

    Setting

    Primary care setting in the Southampton area, UK.

    Patients

    285 children between 6 months and 10 years of age with acute otitis media and information on symptom duration. Exclusion criteria were pink drum alone, otitis media with effusion and chronic suppurative otitis media, serious chronic disease, use of antibiotics in previous 2 weeks, previous complications, or systemic ill health. Follow up was 90%.

    Intervention

    Children were assigned to immediate antibiotics (amoxicillin or erythromycin) {n=135}† or …

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    Footnotes

    • Source of funding: NHS Regional Research and Development.

    • For correspondence: Dr P Little, University of Southampton, Southampton, UK. Psl3{at}soton.ac.uk

    • ↵* See glossary.

    • ↵† Information provided by author.

    • ↵‡

      Little P, Gould C, Williamson I, et al. BMJ 2001;322:336–42.
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