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QUESTION: In patients with carbon monoxide poisoning, is hyperbaric oxygen (HBO) more effective than normobaric oxygen for reducing cognitive sequelae?
Design
Randomised (allocation concealed*), blinded (patients, outcome assessors, and statisticians),* controlled trial with follow up at 6 weeks, 6 months, and 1 year.
Setting
Emergency departments in Utah, Idaho, and Wyoming, USA.
Patients
152 patients (mean age 36 y, 62% men) with documented or obvious exposure to carbon monoxide and any of 11 predetermined symptoms. Patients were excluded if they were <16 years of age, moribund, or pregnant or if >24 hours had elapsed since exposure. Follow up at 6 weeks was 97%.
Intervention
All patients had 3 hyperbaric chamber sessions at intervals of 6–12 hours starting within 24 hours after carbon monoxide exposure. All non-intubated patients received oxygen, 15 l/min via a non-rebreathing face mask and reservoir. Intubated patients were mechanically ventilated with 100% …
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