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Long term mortality and cardiovascular morbidity increased in some patients with asymptomatic mitral valve prolapse

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 QUESTION: In patients with asymptomatic mitral valve prolapse (MVP), what is the prognosis of the disease?

Design

Inception cohort followed for a median of 5.4 years.

Setting

Olmsted County, Minnesota, USA.

Patients

833 patients (median age 47 y) with a first diagnosis of asymptomatic MVP, first suspected by auscultatory findings (n=557) or found incidentally (n=276), confirmed by echocardiography, who were residents of Olmsted County, Minnesota, USA for ≥1 year before diagnosis. Exclusion criteria were notable dyspnoea, angina, or mitral surgery before diagnosis. Follow up was 97%.

Assessment of prognostic factors

Clinical and echocardiographic variables. The degree of mitral regurgitation (MR) was stratified into 3 categories: absent or trivial, …

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Footnotes

  • Source of funding: in part, National Institutes of Health.

  • For correspondence: Dr M Enriquez-Sarano, Mayo Clinic, Rochester, MN, USA.sarano.maurice{at}mayo.edu

  • Abstract and commentary also appear in ACP Journal Club.