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Prognosis
Long term mortality and cardiovascular morbidity increased in some patients with asymptomatic mitral valve prolapse

https://doi.org/10.1136/ebm.8.3.91

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    (2002) Circulation 106, 1355. Avierinos J-F, Gersh BJ, Melton LJ 3rd, et al.. Natural history of asymptomatic mitral valve prolapse in the community.. ;. :. –61.
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 QUESTION: In patients with asymptomatic mitral valve prolapse (MVP), what is the prognosis of the disease?

    Design

    Inception cohort followed for a median of 5.4 years.

    Setting

    Olmsted County, Minnesota, USA.

    Patients

    833 patients (median age 47 y) with a first diagnosis of asymptomatic MVP, first suspected by auscultatory findings (n=557) or found incidentally (n=276), confirmed by echocardiography, who were residents of Olmsted County, Minnesota, USA for ≥1 year before diagnosis. Exclusion criteria were notable dyspnoea, angina, or mitral surgery before diagnosis. Follow up was 97%.

    Assessment of prognostic factors

    Clinical and echocardiographic variables. The degree of mitral regurgitation (MR) was stratified into 3 categories: absent or trivial, …

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    Footnotes

    • Source of funding: in part, National Institutes of Health.

    • For correspondence: Dr M Enriquez-Sarano, Mayo Clinic, Rochester, MN, USA.sarano.maurice{at}mayo.edu

    • Abstract and commentary also appear in ACP Journal Club.