You are here

Article Text

Article menu
Download PDFPDF
Therapeutics
Pravastatin was not better than usual care in reducing all cause mortality or CHD events

https://doi.org/10.1136/ebm.8.4.106

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    (2002) JAMA 288, 2998. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT).. Major outcomes in moderately hypercholesterolemic, hypertensive patients randomized to pravastatin vs usual care.. ;. :. –3007.
    OpenUrlCrossRefPubMedWeb of Science

    
 
 QUESTION: In older patients with well controlled hypertension and moderately elevated low density lipoprotein cholesterol (LDL-C), is pravastatin better than usual care in reducing all cause mortality and coronary heart disease (CHD) events?

    Design

    Randomised (allocation concealed*), unblinded,* controlled trial with mean 4.8 years of follow up (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial [ALLHAT-LLT]).

    Setting

    513 clinical centres in the US, Canada, Puerto Rico, and the US Virgin Islands.

    Patients

    10 355 patients (mean age 66 y, 51% men) who were enrolled in the ALLHAT (age ≥55 y and stage 1 or 2 hypertension with ≥1 additional risk factor for CHD; fasting LDL-C concentration 3.1–4.9 mmol/l for those with no known CHD, or 2.6–3.3 mmol/l for those with known …

    View Full Text

    Footnotes

    • Sources of funding: National Heart, Lung, and Blood Institute and Pfizer.

    • For correspondence: Dr J L Probstfield, University of Washington Medical Center, Seattle, WA, USA. jeffp{at}swog.fhcrc.org. Dr B R Davis, University of Texas-Houston Health Science Center, Houston, TX, USA. bdavis{at}sph.uth.tmc.edu

    • Abstract and commentary also appear in ACP Journal Club

    • ↵* See glossary.