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QUESTION: In children with persistent nasal discharge (rhinosinusitis) for ≥10 days, are antibiotics more effective than placebo or standard treatment for reducing the rate of overall clinical failure?
Studies were identified by searching the Cochrane Controlled Trials Register, Medline (1999–2002), and EMBASE/Excerpta Medica (1997–2002). Bibliographies of relevant articles were reviewed and experts in the field and major pharmaceutical companies (with offices in Australia) were contacted for unpublished studies.
Studies were selected if they were randomised controlled trials (RCTs) comparing antibiotics (effective against Streptococcus pneumoniae and non-capsular Haemophilus influenzae) with placebo or standard treatment (decongestants or nasal saline drops) (control group), and patients were children <18 years of age with nasal discharge that had persisted for ≥10 days
Data were extracted on study setting, sample size, details of the …
Sources of funding: National Health and Medical Research Council and Acute Respiratory Infection Cochrane Review Group.
For correspondence: Dr P Morris, Menzies School of Health Research, Darwin, Northern Territory, Australia.