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White matter changes, creatinine, age, and ankle arm index predicted incident MRI defined infarctions in older adults
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 QUESTION: In older adults whose baseline magnetic resonance imaging (MRI) scan showed no infarctions, what are predictors of infarctions defined by serial cranial MRI?

Design

Cohort study with mean and median follow up of 5 years (range 3.2–7.5 y).

Setting

4 communities in North Carolina, California, Maryland, and Pennsylvania, USA.

Participants

1433 adults ≥65 years of age with no infarctions shown on baseline MRI scan who were able to give informed consent and to respond to questions without the aid of a surrogate respondent.

Assessment of risk factors

Baseline data on blood pressure, ankle arm index, cognitive function, activities of daily living (ADL), instrumental ADL, and depression were collected by questionnaires, physical examination, and laboratory tests.

Main outcome measure

Incident infarction defined by follow up serial cranial MRI scan, identified by neuroradiologists blinded to participants' clinical information.

Main results

On the follow up MRI scan, 254 participants (18%) had ≥1 …

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