Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
QUESTION: In older people with hypertension, is a regimen based on angiotensin converting enzyme (ACE) inhibitors more effective than one based on diuretics for reducing cardiovascular events and all cause mortality?
Randomised (allocation concealed*), blinded (outcome assessors),* controlled trial with median follow up of 4.1 years (Second Australian National Blood Pressure Study [ANBP2]).
1594 family medical practices in Australia.
6083 patients who were 65–84 years of age (mean age 72 y, 51% women) without recent (previous 6 mo) cardiovascular events and had hypertension (defined as systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥90 mm Hg with systolic blood pressure ≥140 mm Hg). Exclusion criteria included any life threatening illness, a plasma creatinine concentration >221 μmol/l, malignant hypertension, and dementia. Follow up was 100%.
Patients were allocated to a treatment regimen …