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Therapeutics
A topical cream containing glucosamine and chondroitin sulphate reduced joint pain in osteoarthritis of the knee

https://doi.org/10.1136/ebm.8.5.154

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    (2003) J Rheumatol 30, 523. Cohen M, Wolfe R, Mai T, et al.. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee.. ;. :. –8.
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 QUESTION: In patients with osteoarthritis of the knee, is a topical cream containing glucosamine sulphate, chondroitin sulphate, and camphor more effective than placebo for relieving joint pain?

    Design

    Randomised (allocation concealed*), blinded (patients, healthcare providers, and data collectors)*, controlled trial with 8 weeks of follow up.

    Setting

    An outpatient clinic at Monash Medical Center, Australia.

    Patients

    63 patients with objectively documented osteoarthritis of the knee who had had knee pain rated >4 cm on a 10 cm visual analogue scale in one or both knees for >4 weeks. Exclusion criteria included women of childbearing age who were not using contraception or were pregnant, and patients who had a regular requirement for analgesia for conditions unrelated to osteoarthritis or had used oral or topical glucosamine in the previous 6 weeks. Follow up was 94% (mean age 63 y, 54% women).

    Intervention

    Patients were allocated …

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    Footnotes

    • Sources of funding:Nutrasense Australia Pty, Ltd. and Smart Science Laboratories Inc.

    • For correspondence: Prof M Cohen, RMIT University, Bundoora, Victoria, Australia. marc.cohen{at}rmit.edu.au

    • ↵* See glossary.

    • ↵† Information provided by author.