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A topical cream containing glucosamine and chondroitin sulphate reduced joint pain in osteoarthritis of the knee

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 QUESTION: In patients with osteoarthritis of the knee, is a topical cream containing glucosamine sulphate, chondroitin sulphate, and camphor more effective than placebo for relieving joint pain?


Randomised (allocation concealed*), blinded (patients, healthcare providers, and data collectors)*, controlled trial with 8 weeks of follow up.


An outpatient clinic at Monash Medical Center, Australia.


63 patients with objectively documented osteoarthritis of the knee who had had knee pain rated >4 cm on a 10 cm visual analogue scale in one or both knees for >4 weeks. Exclusion criteria included women of childbearing age who were not using contraception or were pregnant, and patients who had a regular requirement for analgesia for conditions unrelated to osteoarthritis or had used oral or topical glucosamine in the previous 6 weeks. Follow up was 94% (mean age 63 y, 54% women).


Patients were allocated …

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  • Sources of funding:Nutrasense Australia Pty, Ltd. and Smart Science Laboratories Inc.

  • For correspondence: Prof M Cohen, RMIT University, Bundoora, Victoria, Australia. marc.cohen{at}

  • * See glossary.

  • Information provided by author.