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QUESTION: Is mild, moderate, or severe diastolic dysfunction predictive of all cause mortality?
Design
Cohort study with median 3.5 person years of follow up.
Setting
Olmsted County, Minnesota, USA.
Participants
2042 of 4203 eligible, invited adults who were ≥45 years of age (mean age 63 y), resided in Olmsted County, Minnesota, and were participants in the Rochester Epidemiology Project.
Assessment of risk factors
Blood pressure, height, weight and body mass index; clinical diagnoses of hypertension, myocardial infarction, coronary artery disease, and diabetes mellitus; determination of congestive heart failure (CHF) diagnosis (validated using Framingham criteria); and preclinical diastolic or systolic dysfunction (no diagnosis of CHF, but with either diastolic or systolic dysfunction determined by echocardiography) were measured. Systolic function was categorised by ejection fraction (EF) ≤50% and ≤40%. Diastolic function was categorised as mild (impaired relaxation without increased filling pressures), moderate (impaired relaxation associated with …
Footnotes
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Sources of funding: National Institutes of Health; Marriott Foundation; Miami Heart Research Institute; Mayo Foundation.
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For correspondence: Dr M M Redfield, Mayo Clinic, Rochester, MN, USA. redfield.margaret{at}mayo.edu
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Abstract and commentary also appear in ACP Journal Club.