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Aetiology
Diastolic dysfunction was predictive of all cause mortality

https://doi.org/10.1136/ebm.8.5.157

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    (2003) JAMA 289, 194. Redfield MM, Jacobsen SJ, Burnett JC Jr, et al.. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic.. ;. :. –202.
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 QUESTION: Is mild, moderate, or severe diastolic dysfunction predictive of all cause mortality?

    Design

    Cohort study with median 3.5 person years of follow up.

    Setting

    Olmsted County, Minnesota, USA.

    Participants

    2042 of 4203 eligible, invited adults who were ≥45 years of age (mean age 63 y), resided in Olmsted County, Minnesota, and were participants in the Rochester Epidemiology Project.

    Assessment of risk factors

    Blood pressure, height, weight and body mass index; clinical diagnoses of hypertension, myocardial infarction, coronary artery disease, and diabetes mellitus; determination of congestive heart failure (CHF) diagnosis (validated using Framingham criteria); and preclinical diastolic or systolic dysfunction (no diagnosis of CHF, but with either diastolic or systolic dysfunction determined by echocardiography) were measured. Systolic function was categorised by ejection fraction (EF) ≤50% and ≤40%. Diastolic function was categorised as mild (impaired relaxation without increased filling pressures), moderate (impaired relaxation associated with …

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